Astrocytic ablation of truncated TrkB receptors reduces amyloid plaques and prevents synaptic loss in 5xFAD mice
Robert Bass, Hannah Masterson, YuTing Chen, Baoji Xu
This study shows that reducing TrkB.T in astrocytes reduces amyloid plaques and prevents synaptic loss in 5xFAD mice by enhancing BDNF-TrkB.FL signaling.
bioRxiv · Oct 24, 2026 · PreprintNeuroscience