Sequential Activation of Guide RNAs for Algorithmic Multiplexing of Cas9 Activities
Ryan Clarke, Alexander R. Terry, Hannah Pennington, Matthew S. MacDougall, Maureen R. Regan, Bradley J. Merrill
The paper introduces a system for sequentially activating guide RNAs to control genetic manipulations in mammalian cells using Cas9, enabling preprogrammed cascades of gene editing events.
bioRxiv · Jun 20, 2020 · PreprintSynthetic Biology