Author

Matthew S. MacDougall

University of Illinois ChicagoORCID 0000-0002-7946-6721Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Bradley J. MerrilliD· 2 shared Maureen R. Regan· 2 shared Ryan ClarkeiD· 2 shared Alejandro ChaveziD· 1 shared Alexander R. TerryiD· 1 shared George McDonald ChurchiD· 1 shared Hannah Pennington· 1 shared Leslyn A. HanakahiiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Bradley J. MerrillORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintJun 20, 2020

Sequential Activation of Guide RNAs for Algorithmic Multiplexing of Cas9 Activities

Ryan Clarke, Alexander R. Terry, Hannah Pennington…·Bradley J. Merrill

The paper introduces a system for sequentially activating guide RNAs to control genetic manipulations in mammalian cells using Cas9, enabling preprogrammed cascades of gene editing events.

DOI 10.1101/2020.06.20.162982

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyMolecular CellPeer-reviewedJul 1, 2018

Enhanced bacterial immunity and mammalian genome editing via RNA polymerase-mediated dislodging of Cas9 from double strand DNA breaks.

Ryan Clarke, Robert Heler, Matthew S. MacDougall…·Bradley J. Merrill

This paper shows that RNA polymerase can dislodge Cas9 from DNA breaks, improving genome editing and bacterial immunity by increasing mutagenesis and phage resistance.

143 citationstop 2%

bacteria (other)human

𝕏 PostBluesky