MsyB-HU Interaction Modulates a Two-Tiered Bacterial Stress Response by Regulating DNA Supercoiling
Huan Chen, Yanan Yang, Xinrui Chen, Haolong Zhou, Yingli He, Mengzhe Li, Wei Lin, Zuyi Yuan, Yawen Wang, Stephen Matthews, Shuai Yuan, Hongliang Wang, Bing Liu
This study identifies MsyB as a HU inhibitor and β-clamp binder in E. coli, showing it modulates DNA supercoiling to influence transcription and adaptive mutation under stress.
bioRxiv · Feb 25, 2025 · PreprintMicrobiology