Enhanced maturation of human stem cell derived cortical interneurons by mTOR activation
Jianhua Chu, Megan L. Fitzgerald, Neha Sehgal, William Manley, Shane M. Fitzgerald, Harrison Naung, Ethan M. Goldberg, Stewart A. Anderson
This study accelerates the maturation of human stem cell-derived cortical interneurons by activating mTOR signaling through PTEN deletion or AKT activation, enhancing synaptogenesis and dendritogenesis.
bioRxiv · Nov 20, 2019 · PreprintNeuroscience