Stewart A. Anderson

Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates RTFDC1 at the CASS4 locus

The paper maps GWAS variants associated with late-onset Alzheimer's disease to functional effects in microglial cells, identifying RTFDC1 as a novel effector gene at the CASS4 locus.

Shared and unique chromatin accessibility and 3D functional interactions of substance use disorder loci implicate cell types beyond the brain

This paper identifies shared and unique chromatin accessibility and 3D interactions of SUD loci, implicating non-neural cell types like pancreatic β-cells and showing a causal link between T2D and AUD.

Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2

The paper identifies rs7132908 as a causal variant in the chr12q13 obesity locus, showing it affects FAIM2 expression and neurodevelopment through cis-regulatory mechanisms.

Interneurons that BiTE: Harnessing the migratory capacity of cortical inhibitory interneuron precursors to treat high-grade glioma

This paper develops a method using migratory cortical interneuron precursors to deliver therapeutic agents directly to glioblastoma, improving survival in mice.

Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behavior

This study shows mitochondrial dysfunction in the blood-brain barrier of 22qDS patients and mice, leading to impaired barrier function and social memory, which is corrected by mitochondrial treatment.

Disruption of the blood brain barrier in 22q11.2 deletion syndrome

This study shows that the blood brain barrier in 22q11.2 deletion syndrome is compromised, leading to increased neuroinflammation and potential risk for neuropsychiatric disorders.

Enhanced maturation of human stem cell derived cortical interneurons by mTOR activation

This study accelerates the maturation of human stem cell-derived cortical interneurons by activating mTOR signaling through PTEN deletion or AKT activation, enhancing synaptogenesis and dendritogenesis.

Single Cell Spatial Chromatin Analysis of Fixed Immunocytochemically Identified Neuronal Cells

CHEX-seq identifies open-chromatin regions in fixed single cells, enabling spatial chromatin analysis in complex environments.