BiophysicsStructurePeer-reviewed
Constitutive activity of ionotropic glutamate receptors via hydrophobic substitutions in the ligand-binding domain
Sandra Seljeset, Oksana V. Sintsova, Yuhong Wang…·Timothy Lynagh
The paper identifies a conserved aspartate residue in NMDA receptors that controls ligand potency and activity, showing substitutions can bypass ligand binding and reveal evolutionary adaptations in a homomeric iGluR.
5 citations