Cell-type-specific patterns and consequences of somatic mutation in development and aging brain
Andrea J. Kriz, Shulin Mao, Diane D. Shao, Daniel A. Snellings, Rebecca Andersen, Guanlan Dong, Chanthia C. Ma, Hayley E. Cline, August Yue Huang, Eunjung Alice Lee, Christopher A. Walsh
The paper introduces Duplex-Multiome, a method to identify cell-type-specific somatic mutations in brain tissue, revealing age-related mutation patterns and developmental lineage relationships.
bioRxiv · May 30, 2025 · PreprintGenomics