Andrea J. Kriz

The paper investigates somatic copy number variants (CNVs) in human neurons across development, finding that perinatal elimination of neurons with aberrant genomes reduces CNV prevalence and targets dosage-sensitive genes.

The paper introduces Duplex-Multiome, a method to identify cell-type-specific somatic mutations in brain tissue, revealing age-related mutation patterns and developmental lineage relationships.

The paper uses spatial single-cell analysis to uncover molecular and structural development of human fetal cortex, revealing early layer and area specification.

This study investigates how cohesin depletion or retention affects X-inactivation and chromosomal interactions, finding that cohesin balance is critical for proper Xi structure and gene silencing.

The paper investigates the role of megadomains and superloops in X chromosome inactivation, finding they are not required for silencing or gene escape.