Author

Heather L. Darling

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Biology Disciplines

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Günter P. Wagner· 1 shared Jens Meiler· 1 shared Laura S. Mizoue· 1 shared Mauris C. Nnamani· 1 shared Monika Fuxreiter· 1 shared Soumya Ganguly· 1 shared Vincent J. Lynch· 1 shared Yingchun Tong· 1 shared

Activity by Year

2015-2015 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperEvolutionary Biology

Günter P. Wagner

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1 paper

Recent·Most cited

Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

Mauris C. Nnamani, Soumya Ganguly, Vincent J. Lynch, Laura S. Mizoue, Yingchun Tong, Heather L. Darling, Monika Fuxreiter, Jens Meiler, Günter P. Wagner

This study investigates how the functional interaction between HOXA11 and FOXO1 evolved through allosteric regulation, showing TF function can change via modifications to pre-existing protein complexes.

bioRxiv · Jan 26, 2015 · PreprintEvolutionary Biology