Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve
Yaeram Jeong, Chung-ha O. Davis, Aaron M. Muscarella, Hector H Navarro, Viraj A. Deshpande, Lucy G. Moore, Keun-young Kim A, Mark H. Ellisman, Nicholas Marsh‐Armstrong
The paper investigates how glaucoma-associated Optineurin mutations affect transmitophagy in Xenopus laevis optic nerves, finding increased mitochondrial shedding and degradation by astrocytes.
eLife · Aug 12, 2025Peer-reviewedNeuroscience