Nicholas Marsh‐Armstrong

This study investigates how mitochondrial dysfunction and immune activation contribute to retinal ganglion cell degeneration in optic neuropathy using transgenic models.

The paper investigates how glaucoma-associated Optineurin mutations affect transmitophagy in Xenopus laevis optic nerves, finding increased mitochondrial shedding and degradation by astrocytes.

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

The paper shows that during human retinal ganglion cell differentiation, the mitochondrial degradation pathway shifts from the ubiquitine-proteasome system to the endo-lysosomal pathway, which is critical for cell survival.