Author

Heidi Carias Martinez

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Ala M. ShaqraiD· 1 shared Celia A. SchifferiD· 1 shared Daniel N. A. BoloniD· 1 shared Dustin DovalaiD· 1 shared Julia M. FlynniD· 1 shared Neşe Kurt YılmaziD· 1 shared Sarah N. ZvornicaniniD· 1 shared Stephanie A. MoquiniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Ala M. ShaqraORCID

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1 paper

Recent·Most cited

Molecular Mechanisms of Drug Resistance and Compensation in SARS-CoV-2 Main Protease: The Interplay Between E166 and L50

Sarah N. Zvornicanin, Ala M. Shaqra, Julia M. Flynn, Heidi Carias Martinez, Weiping Jia, Stephanie A. Moquin, Dustin Dovala, Daniel N. A. Bolon, Neşe Kurt Yılmaz, Celia A. Schiffer

This study investigates drug resistance mechanisms in SARS-CoV-2 Mpro caused by E166 mutations and their compensation by L50F, revealing structural and functional impacts on inhibitor binding and catalytic efficiency.

mBio · Apr 9, 2025Peer-reviewedBiochemistry