Homologous recombination-based genome editing by clade F AAVs is inefficient in the absence of a targeted DNA break
Geoffrey L. Rogers, Hsu-Yu Chen, Heidy Morales, Paula M. Cannon
The paper evaluates clade F AAVs for homologous recombination-based genome editing without DSBs, finding no detectable editing without ZFNs.
Molecular Therapy · Sep 9, 2019Peer-reviewedSynthetic Biology