Keratinocyte Arginase1 Deficiency Impairs Healing and Antimicrobial Defence against Pseudomonas aeruginosa Infection
Rachel A Crompton, Denis C. Szondi, Christopher Doherty, Helen A. Thomason, Sze Han Lee, Yan Ping Loh, Catherine A. O’Neill, Leah A. Vardy, Andrew J. McBain, Sheena Margaret Cruickshank
This study shows that keratinocyte arginase1 deficiency impairs wound healing and antimicrobial defense against Pseudomonas aeruginosa by reducing epithelial proliferation and anti-microbial peptide production.
bioRxiv · Feb 24, 2025 · PreprintMicrobiology