CD11c+ myeloid cells are the predominant CD4+CCR5+ immune population in the foreskin and are increased in men with HIV-associated penile anaerobes
Lane B Buchanan, Yazan N. Khan, Jorge R Vargas, Zhongtian Shao, Victoria Menya Biribawa, HenryRoger Ssemunywa, Annemarie Namuniina, Brenda Apio Okech, Aaron A.R. Tobian, Daniel E. Park, Cindy M. Liu, Rupert Kaul, Ronald Moses Galiwango, Jessica L. Prodger
The paper investigates the association between penile anaerobic bacteria and immune cell densities in foreskin tissue, finding increased CD11c+ myeloid cells and HIV-susceptible T cells in individuals with high bacterial abundance.
bioRxiv · May 14, 2026 · PreprintImmunology