Ribosomal RNA transcription governs splicing through ribosomal protein RPL22
Wenjun Fan, Hester Liu, Gregory C. Stachelek, Asma Begum, Catherine E. Davis, Tony E. Dorado, Glen E. Ernst, William C. Reinhold, Büşra Özbek, Qizhi Zheng, Angelo Michael De Marzo, N.V. Rajeshkumar, James C. Barrow, Marikki Laiho
The paper identifies RPL22 as a splicing regulator linking rRNA synthesis to mRNA splicing, showing that Pol I inhibition reverses RPL22-dependent alternative splicing.
bioRxiv · Aug 15, 2024 · PreprintMolecular Biology