James C. Barrow

This study develops a novel benzodiazepine, Li633, that targets peripheral GABAA receptors to reduce visceral pain in IBS and FD models.

The paper identifies RPL22 as a splicing regulator linking rRNA synthesis to mRNA splicing, showing that Pol I inhibition reverses RPL22-dependent alternative splicing.

This study shows that degraded stimuli impair performance in a mouse continuous performance test, mirroring human findings and supporting the translational value of the rodent model.

This study shows that adolescent social isolation in mice affects reward-seeking behavior differently in males and females, with males showing increased sensitivity and reward-seeking.

The paper identifies novel COMT inhibitors that improve cognitive flexibility in rats by modulating dopamine metabolites in the frontal cortex and cerebrospinal fluid.

This study investigates the effects of COMT inhibition on effort-related choice behavior in male mice and finds no significant impact on task performance.

The paper uses hiPSC transcriptomics to study neuronal differentiation and maturation across multiple conditions and develops a tool to estimate neuronal maturity.

This study evaluates the use of PC12 cells as an in vitro platform to screen COMT inhibitors, showing that tolcapone and LIBD-3 increase dopamine and DOPAC while reducing 3-MT and HVA.