A macrocyclic peptide-based fusion inhibitor targeting SARS-CoV-2 Spike S2 subunit
Hirofumi Ohashi, Tatsuro Kawamura, Masaki Ohuchi, Haruaki Kurasaki, Naoko Iwata‐Yoshikawa, Yuichiro Hirata, Saya Moriyama, Kaho Shionoya, Kazutaka Nagatomo, Takayuki Nagasawa, Junpei Yamamoto, Kei Sudo, Naoko Nakamura, Katsuma Matsui, Haruhiko Ogawa, , Koichi Watashi
This paper identifies PA-001, a macrocyclic peptide that inhibits SARS-CoV-2 infection by targeting the S2 subunit's FPPR region, showing broad antiviral activity and efficacy in animal models and clinical trials.
bioRxiv · Mar 6, 2026 · PreprintMicrobiology