Koichi Watashi

Systematic analysis of intracellular replication competence of mammalian, avian, and reptilian kolmioviruses.

The paper examines the replication competence of KoVs in cell lines from different vertebrate classes, finding host-specific replication patterns consistent with phylogenetic groupings.

E3 ubiquitin ligase HUWE1 mediates K6-linked polyubiquitylation and stabilization of Nrf2 to restrict hepatitis B virus replication

A macrocyclic peptide-based fusion inhibitor targeting SARS-CoV-2 Spike S2 subunit

This paper identifies PA-001, a macrocyclic peptide that inhibits SARS-CoV-2 infection by targeting the S2 subunit's FPPR region, showing broad antiviral activity and efficacy in animal models and clinical trials.

Disruption of the NTCP-EGFR receptor complex as a strategy for selective inhibition of hepatitis B and D virus entry

This study identifies Oxy229, a compound that disrupts the NTCP-EGFR receptor complex, selectively inhibiting HBV and HDV entry without affecting NTCP or EGFR physiological functions.

Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

Required concentration index quantifies effective drug combinations against HCV infection

The paper introduces a required concentration index to rank antiviral efficacy of HCV drug combinations and shows multidrug treatments enhance activity but reduce genotype-specific efficacy.