Time-dependent processing of dengue virus polyprotein yields multiple capsid forms that disrupt cellular homeostasis
Preeti Chauhan, Himanshu Vankhede, Sakshi Rawat, Deepti Maisnam, Lekha Gandhi, Deepika Rathore, Akash Gulyani, Musturi Venkataramana
This study identifies time-dependent dengue virus polyprotein processing into multiple capsid forms that disrupt mitochondrial homeostasis, with ursonic acid shown to restore mitochondrial function and inhibit viral replication.
bioRxiv · Oct 2, 2025 · PreprintMicrobiology