Active Nuclear Shuttling Enables Efficient Virus-Free CAR Gene Integration Using Ready-to-Use Lipid Nanoparticles
Kota Inoue, Misaki Masui, Sayako Umetani, Kazuhiko Nakata, Kohei Shimizu, Kohei Yasuda, Kenataro Numajiri, Yuta Murakami, Shinichi Hashimoto, Hirofumi Fukunaga, Nao Suzuki‐Yamazaki
This study develops a virus-free CAR-T cell manufacturing platform using lipid nanoparticles and nuclear localization signals to enhance genomic integration and cell viability.
bioRxiv · Jun 2, 2026 · PreprintBioengineering