Shinichi Hashimoto

This study develops a virus-free CAR-T cell manufacturing platform using lipid nanoparticles and nuclear localization signals to enhance genomic integration and cell viability.

This study shows that hypomorphic Lig4 mutation in mice causes Th1-skewed intestinal inflammation under adaptive immunodeficiency.

This study characterizes peritoneal exudate cells in liver cirrhosis patients using single-cell and bulk RNA sequencing, revealing shifts in immune cell populations and gene expression with disease severity.