A Conserved Stress-Inducible Hub Enhancer Governs Natriuretic Peptide Expression and Undergoes Dynamic and Reversible Activation in Human Heart Failure
Ken Matsuoka, Hijiri Inoue, Jo Hyejin, Chisato Okamoto, Hirona Hasuike, Hai Ying Fu, Hidetaka Kioka, Yuki Kuramoto, Takatsugu Segawa, Shunsuke Nishimura, Rina Takamiya, Yohei Miyashita, Yoshihiro Asano, Satoru Yamazaki, Hisakazu Kato, , Osamu Tsukamoto
This study identifies CR9 as a stress-inducible hub enhancer critical for natriuretic peptide expression in heart failure, showing its reversible activation in human hearts.
bioRxiv · Oct 13, 2025 · PreprintMolecular Biology