Author

Osamu Tsukamoto

Hyogo Medical UniversityORCID 0000-0002-9504-8001Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Chisato OkamotoiD· 2 shared Hijiri Inoue· 2 shared Hisakazu KatoiD· 2 shared Ken MatsuokaiD· 2 shared Seiji TakashimaiD· 2 shared Hai Ying Fu· 1 shared Hidetaka KiokaiD· 1 shared Hirona Hasuike· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Chisato OkamotoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A Conserved Stress-Inducible Hub Enhancer Governs Natriuretic Peptide Expression and Undergoes Dynamic and Reversible Activation in Human Heart Failure

Ken Matsuoka, Hijiri Inoue, Jo Hyejin, Chisato Okamoto, Hirona Hasuike, Hai Ying Fu, Hidetaka Kioka, Yuki Kuramoto, Takatsugu Segawa, Shunsuke Nishimura, Rina Takamiya, Yohei Miyashita, Yoshihiro Asano, Satoru Yamazaki, Hisakazu Kato, , Osamu Tsukamoto

This study identifies CR9 as a stress-inducible hub enhancer critical for natriuretic peptide expression in heart failure, showing its reversible activation in human hearts.

bioRxiv · Oct 13, 2025 · PreprintMolecular Biology

HiFAA: a high-confidence framework for transcription factor footprinting with ATAC-seq

Hijiri Inoue, Chisato Okamoto, Hisakazu Kato, Osamu Tsukamoto, Seiji Takashima, Ken Matsuoka

HiFAA improves TF footprint detection from ATAC-seq by integrating domain-restricted analysis, single-base resolution, and footprint ranking, enhancing sensitivity and specificity.

bioRxiv · Oct 11, 2025 · PreprintBioinformatics