Kinetic asymmetry drives kinesin-1's unidirectional and processive movement
Hiroshi Isojima, Kohei Matsuzaki, Michio Tomishige
This study investigates how kinesin-1 moves unidirectionally by comparing biased-diffusion and biased-binding mechanisms, finding that kinetic asymmetry in binding and detachment drives its processive motion.
bioRxiv · Jun 11, 2025 · PreprintBiophysics