Michio Tomishige

This study investigates how kinesin-1 moves unidirectionally by comparing biased-diffusion and biased-binding mechanisms, finding that kinetic asymmetry in binding and detachment drives its processive motion.

This study investigates how the neck linker's conformation affects kinesin-1's stepping mechanism by analyzing its kinetic effects on ATP and microtubule interactions.

This study shows that tension in the neck linker of kinesin-1 suppresses premature binding of the detached head, explaining coordinated stepping through allosteric regulation.