Calcineurin inhibition deactivates pyruvate dehydrogenase and induces proximal tubule cell metabolic dysfunction, causing profibrotic phenotype
Yasuhiro Oda, Hiroshi Nishi, Fumie Hamano, Teruhiko Yoshida, Yoshihiro Kita, Jeffrey B. Kopp, Masaomi Nangaku
The paper shows that calcineurin inhibition deactivates pyruvate dehydrogenase, leading to proximal tubule cell metabolic dysfunction and kidney fibrosis.
Journal of the American Society of Nephrology · Aug 29, 2025Peer-reviewedMolecular Biology