Masaomi Nangaku

REN-former identifies gene regulators of kidney disease transitions by combining single-cell modeling and human genetics.

The paper introduces OASSIS, an open-format digital bioassay platform that enables sensitive, low-complexity RNA detection for point-of-care testing.

This paper applies geographically weighted regression to spatial transcriptomics data to identify spatially coupled M2 macrophages and fibrosis in DKD, finding enriched IgE-related genes in high-coupling spots.

The paper shows that calcineurin inhibition deactivates pyruvate dehydrogenase, leading to proximal tubule cell metabolic dysfunction and kidney fibrosis.

This study shows that Kdm7a regulates posterior Hox gene expression in mouse embryos by demethylating H3K9me2, leading to anterior-posterior developmental defects.

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.