SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2
Andrés Hernández, Katherine E. Pendleton, Sangbae Kim, Yumei Li, Bum Joon Kim, Hitisha P. Zaveri, Valerie K. Jordan, Aliska M. Berry, M. Cecilia Ljungberg, Rui Chen, Rainer B. Lanz, Daryl A. Scott
The paper shows SOX7 deficiency causes ventricular septal defects by impairing endocardial-to-mesenchymal transition through reduced Wnt4 and Bmp2 expression in developing atrioventricular canals.
Human Molecular Genetics · Mar 31, 2023Peer-reviewedDevelopmental Biology