MYC-MIZ1 Complexes at Enhancers Tune Neuroendocrine Identity of Small Cell Lung Cancer
Lisa Marie Fröhlich, Hannah Lea Tumbrink, Bikash Adhikari, Margarita Rempe, Jenny Ostendorp, Paula Zickler, Michaela Nicole Hoehne, Alena Heimsoeth, Yichun Tang, Stefanie Lennartz, Ayla E. Schwäbe, Lisa Werr, Matthias Fischer, Alexander Quaas, Holger Gruell, , Martin L. Sos
This study identifies Miz1/Myc complexes at enhancers as key regulators of neuroendocrine identity in SCLC, showing their role in gene expression and chemosensitivity.
bioRxiv · Aug 20, 2026 · PreprintCancer Biology