Elmar Wolf

This study identifies Miz1/Myc complexes at enhancers as key regulators of neuroendocrine identity in SCLC, showing their role in gene expression and chemosensitivity.

This study shows that arginine depletion induces senescence and stress response in pancreatic cancer cells, making them susceptible to senolysis and stress response inhibition.

The paper introduces AIDE, a tool for minute-scale degradation of bacterial effectors in host cells, revealing dynamic roles of specific effectors in infection.

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

This paper introduces a miniaturized PROTAC synthesis workflow that bypasses compound purification, enabling rapid screening and degradation assessment of multiple targets.

This paper introduces a rapamycin-induced proximity assay (RiPA) to identify effective E3 ligase-target pairs for PROTAC development, demonstrating its ability to predict degradation capabilities.

The paper develops computational methods to correct 4sU-induced quantification bias in nucleotide conversion RNA-seq data by addressing mappability and reverse transcription efficiency issues.

The paper shows that NONO relocalizes to the nucleolus via diNARs to shield DNA breaks from aberrant transcripts, promoting repair.