Ciliary cAMP regulates Shh signal interpretation to drive polarisation of differentiating neurons
Gabriela Toro-Tapia, Holly B Burbidge, Veronica Biga, John Robert Davis, Raman M Das
This study shows that ciliary cAMP levels regulate Shh signal interpretation during neuron differentiation by balancing Smo and GPR161 to control actin dynamics and polarisation.
bioRxiv · Mar 12, 2026 · PreprintDevelopmental Biology