Author

Hong-Kee Tan

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Andrew J. WatersiD· 1 shared Anna KolesnikiD· 1 shared Daniel P. GittermaniD· 1 shared David J. AdamsiD· 1 shared Elise Ng‐CordelliD· 1 shared Elizabeth J. RadfordiD· 1 shared Eugene J. GardneriD· 1 shared Federico AbascaliD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Andrew J. WatersORCID

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1 paper

Recent·Most cited

Saturation genome editing of DDX3X clarifies pathogenicity of germline and somatic variation

Elizabeth J. Radford, Hong-Kee Tan, Malin H. L. Andersson, James D. Stephenson, Eugene J. Gardner, Holly Ironfield, Andrew J. Waters, Daniel P. Gitterman, Sarah Lindsay, Federico Abascal, Iñigo Martincorena, Anna Kolesnik, Elise Ng‐Cordell, Helen V. Firth, Kate Baker, , Matthew E. Hurles

The paper uses saturation genome editing to assess DDX3X variants' functional impact, identifies pathogenic variants for neurodevelopmental disorders, and develops a classifier outperforming existing tools.

Nature Communications · Dec 6, 2023Peer-reviewedGenetic & Genomic Medicine