SARS-CoV-2 S protein activates the HIV latent reservoir through the mTOR pathway
Linle Xu, Liangjuan Chen, Hanying Wang, Honglin Shi, Xingzhong Miao, Shiqing Li, Yue Jiang, Hongbo Shi
This study investigates how SARS-CoV-2 S protein affects HIV latent reservoir stability through the mTOR pathway, finding that S proteins activate the reservoir and this effect is mediated by mTOR.
bioRxiv · Aug 18, 2025 · PreprintImmunology