Cell BiologybioRxivPreprint
Lactate metabolism antagonizes antiviral innate immunity bypromoting VDAC1-lactylation-mediated mtDNA release
Yi Wu, Lu Li, Yiyi Liu…·Junwei Cao
This study shows FMDV infection in horse cells increases lactate, which modifies VDAC1 and promotes mtDNA release, activating cGAS-STING and reducing viral replication.
DOI 10.1101/2025.05.09.653027