METTL3 facilitates hepatic fibrosis progression via m6A-YTHDF2 dependent silencing of GPR161
Xue‐Yin Pan, Yihui Bi, Miao Cheng, Zhenzhen Qian, Ling Wang, Hongmei You, Lei Liu, Zhenhua Zhang, Xiao‐Ming Meng, Cheng Huang, Jun Li
This paper shows that METTL3 promotes hepatic fibrosis by suppressing GPR161 through m6A-YTHDF2 modification, and its depletion alleviates fibrosis by stabilizing GPR161 and inhibiting Hedgehog pathway activation.
bioRxiv · Dec 15, 2021 · PreprintMolecular Biology