Yihui Bi

This study shows MORC2 forms dynamic nuclear condensates through phase separation, essential for transcriptional repression, and links condensate dysfunction to neuropathies.

This paper develops Auto-RS, a computational classifier using autophagy gene expression to predict osteosarcoma prognosis and identify therapeutic vulnerabilities.

This study identifies collagen I as a key inhibitor of axonal regeneration in spinal cord injury and shows that aspirin and pirfenidone reduce collagen I and promote axonal growth.

This paper shows that METTL3 promotes hepatic fibrosis by suppressing GPR161 through m6A-YTHDF2 modification, and its depletion alleviates fibrosis by stabilizing GPR161 and inhibiting Hedgehog pathway activation.