The second lineage differentiation of bovine embryos fails in the absence of OCT4/POU5F1
Kilian Simmet, Mayuko Kurome, Valeri Zakhartchenko, Horst-Dieter Reichenbach, Claudia Springer, Andrea Bähr, Helmut Blum, Julia Philippou‐Massier, Eckhard Wolf
This study shows OCT4 is essential for maintaining pluripotency in the epiblast and differentiation of the hypoblast in bovine embryos.
bioRxiv · Sep 6, 2021 · PreprintDevelopmental Biology