Eckhard Wolf

The paper shows that inhibiting miR-128-3p improves muscle function and reduces aging-related pathology in multiple models.

This study characterizes pancreatic adaptations during porcine pregnancy, identifying new protein targets involved in endocrine cell remodeling and highlighting potential therapeutic targets for gestational diabetes.

This study benchmarks porcine pancreatic ductal organoids (PPDO) against human pancreatic ductal organoids (HPDO) and primary porcine pancreas using scRNA-Seq, showing PPDO's potential for drug screening with conserved toxicity profiles.

This study identifies early impairments in satellite cells of a porcine DMD model using multi-omics analysis, showing intrinsic genetic defects rather than environmental factors.

This study creates a humanized pig model of Usher syndrome type 1, showing disrupted photoreceptor architecture and vision loss, and validates gene therapy approaches.

This study shows OCT4 is essential for maintaining pluripotency in the epiblast and differentiation of the hypoblast in bovine embryos.

This paper generates Cas9-expressing transgenic chickens and pigs for in vivo genome editing, demonstrating their health, fertility, and functionality across multiple tissues and genes.