Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology: How specific are the conformation-specific α-synuclein antibodies?
Senthil T. Kumar, Somanath Jagannath, Cindy François, Hugo Vanderstichele, Erik Stoops, Hilal Ahmed Lashuel
The paper characterizes 16 α-synuclein conformation-specific antibodies using defined preparations of α-synuclein species, finding none are specific to a single species and many recognize fibrils as well as oligomers.
Neurobiology of Disease · Sep 21, 2020Peer-reviewedNeuroscience