Author

Somanath Jagannath

École Polytechnique Fédérale de Lausanne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Hilal Ahmed LashueliD· 3 shared Catherine Strand· 2 shared Janice L. HoltoniD· 2 shared Melek Firat AltayiD· 2 shared Senthil T. KumariD· 2 shared Adriano AguzziiD· 1 shared Anass ChikiiD· 1 shared Anne MicheliD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Hilal Ahmed LashuelORCID

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Author profile →

4 papers

Recent·Most cited

Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes

Weijia Zhong, Carlo Scialò, Beatrice Gatta, Manon Anic Haefliger, Noemi Leu, Flavio Lurati, M Peter, Nandini Ramesh, Bernd Roschitzki, Somanath Jagannath, Ruchi Manglunia, Elena De Cecco, Su Min Lim, Oscar G. Wilkins, Adriano Aguzzi, , Magdalini Polymenidou

The paper investigates factors determining TDP-43 seeding outcomes in FTLD-TDP, identifying TMEM106B fibrillar core and lysosomal escape as critical drivers.

bioRxiv · Dec 22, 2025 · PreprintNeuroscience

Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies

Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Niran Maharjan, Nadine Ait‐Bouziad, Anass Chiki, Somanath Jagannath, Galina Limorenko, Salvatore Novello, Jonathan Ricci, Siv Vingill, Richard Wade‐Martins, Janice L. Holton, Catherine Strand, Caroline Haikal, Jiayi Li, , Hilal Ahmed Lashuel

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

bioRxiv · Nov 29, 2024 · PreprintNeuroscience

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand, Yasuo Miki, Laura Parkkinen, Janice L. Holton, Hilal Ahmed Lashuel

The paper develops and validates an expanded antibody panel to capture diverse alpha-synuclein conformations and modifications in Lewy body diseases.

npj Parkinson s Disease · Dec 7, 2023Peer-reviewedNeuroscience

Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology: How specific are the conformation-specific α-synuclein antibodies?

Senthil T. Kumar, Somanath Jagannath, Cindy François, Hugo Vanderstichele, Erik Stoops, Hilal Ahmed Lashuel

The paper characterizes 16 α-synuclein conformation-specific antibodies using defined preparations of α-synuclein species, finding none are specific to a single species and many recognize fibrils as well as oligomers.

Neurobiology of Disease · Sep 21, 2020Peer-reviewedNeuroscience