Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's Disease
Vibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi Saido, Toh Hean Ch’ng
This study shows that Aβ accumulation in a mouse AD model reduces nuclear pore complex function, leading to impaired nucleocytoplasmic transport and increased vulnerability to necroptosis.
bioRxiv · Jan 8, 2024Neuroscience