Vibhavari Aysha Bansal

Single-cell atlas of the fetal Down syndrome cortex uncovers chromosome 21 regulators of intellectual disability gene networks

The paper constructs a single-cell atlas of fetal Down syndrome cortex, identifying chromosome 21 transcription factors that regulate intellectual disability gene networks and showing their normalization can restore molecular signatures.

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's Disease

This study shows that Aβ accumulation in a mouse AD model reduces nuclear pore complex function, leading to impaired nucleocytoplasmic transport and increased vulnerability to necroptosis.