Preeclampsia in mice carrying fetuses with APOL1 risk variants
Teruhiko Yoshida, Khun Zaw Latt, Shashi Shrivastav, Huiyan Lü, Kimberly J. Reidy, Jennifer R. Charlton, Yongmei Zhao, Cheryl Ann Winkler, Sandra E. Reznik, Avi Z. Rosenberg, Jeffrey B. Kopp
This study uses mouse models to show that fetal APOL1-G1 variants cause preeclampsia by inducing pro-inflammatory responses in placental and maternal monocyte cells.
bioRxiv · Mar 20, 2024 · PreprintMolecular Biology