Cardiac Gq receptors and calcineurin activation are not required for the hypertrophic response to mechanical left ventricular pressure overload
Ze‐Yan Yu, Hutao Gong, Jianxin Wu, Yun Dai, Scott H. Kesteven, Diane Fatkin, Boris Martinac, Robert M. Graham, Michael Patrick Feneley
This study shows that Gq receptors and calcineurin are needed for neurohumoral LVH but not for mechanical TAC-induced LVH, which uses CaMKII-HDAC4-MEF2 pathway.
Frontiers in Cell and Developmental Biology · Feb 15, 2021Peer-reviewedMolecular Biology