The paper identifies genetic variants associated with spontaneous coronary artery dissection using multi-trait GWAS and gene-based analysis, revealing new loci and biological pathways.

1 citation

humanGWAS summary statistics

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GenomicsNature CommunicationsPeer-reviewedJun 9, 2023

Village in a dish: a model system for population-scale hiPSC studies

Drew R. Neavin, Angela M. Steinmann, Nona Farbehi…·Joseph E. Powell

The paper demonstrates that village cultures of hiPSCs maintain consistent transcriptional profiles across uni- and village-cultured samples, enabling population-scale studies.

72 citationstop 2%

humanbulk RNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJul 5, 2022

Genome-wide association meta-analysis of spontaneous coronary artery dissection reveals common variants and genes related to artery integrity and tissue-mediated coagulation

David Adlam, Takiy-Eddine Berrandou, Adrien B. Georges…·Nabila Bouatia‐Naji

This study identifies 17 genetic risk loci for spontaneous coronary artery dissection (SCAD), including 12 new ones, and highlights genes related to artery integrity and coagulation.

5 citations

humanGWAS summary statistics

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Molecular BiologyFrontiers in Cell and Developmental BiologyPeer-reviewedFeb 15, 2021

Cardiac Gq receptors and calcineurin activation are not required for the hypertrophic response to mechanical left ventricular pressure overload

Ze‐Yan Yu, Hutao Gong, Jianxin Wu…·Michael Patrick Feneley

This study shows that Gq receptors and calcineurin are needed for neurohumoral LVH but not for mechanical TAC-induced LVH, which uses CaMKII-HDAC4-MEF2 pathway.

6 citations

mousebulk RNA-seq

𝕏 PostBluesky