Molecular identification of ALDH1A1 and SIRT2 in the astrocytic putrescine-to-GABA metabolic pathway
Mridula Bhalla, Jeong Im Shin, Yeon Ha Ju, Yongmin Mason Park, Seonguk Yoo, Hyeon Beom Lee, Changjoon Justin Lee
The paper identifies ALDH1A1 and SIRT2 as enzymes in the astrocytic putrescine-to-GABA metabolic pathway and suggests they are potential therapeutic targets for Alzheimer's Disease.
bioRxiv · Jan 11, 2023 · PreprintNeuroscience