Author

Seonguk Yoo

Korea Institute of Science and Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1

Frequent Co-Authors

Changjoon Justin LeeiD· 2 shared Mridula BhallaiD· 2 shared Yeon Ha JuiD· 2 shared Yongmin Mason ParkiD· 2 shared Hoon RyuiD· 1 shared Hyeon Beom Lee· 1 shared Hyunbeom LeeiD· 1 shared Il‐Joo ChoiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Changjoon Justin LeeORCID

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2 papers

Recent·Most cited

Molecular identification of ALDH1A1 and SIRT2 in the astrocytic putrescine-to-GABA metabolic pathway

Mridula Bhalla, Jeong Im Shin, Yeon Ha Ju, Yongmin Mason Park, Seonguk Yoo, Hyeon Beom Lee, Changjoon Justin Lee

The paper identifies ALDH1A1 and SIRT2 as enzymes in the astrocytic putrescine-to-GABA metabolic pathway and suggests they are potential therapeutic targets for Alzheimer's Disease.

bioRxiv · Jan 11, 2023 · PreprintNeuroscience

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimers Disease

Yeon Ha Ju, Mridula Bhalla, Seung Jae Hyeon, Ju Eun Oh, Seonguk Yoo, Uikyu Chae, Jea Kwon, Wuhyun Koh, Jiwoon Lim, Yongmin Mason Park, Jung-Hee Lee, Il‐Joo Cho, Hyunbeom Lee, Hoon Ryu, Changjoon Justin Lee

This study shows that astrocytic urea cycle detoxifies Aβ-derived ammonia but impairs memory in Alzheimer's disease, suggesting ODC1 inhibition as a potential therapeutic strategy.

Cell Metabolism · Jun 22, 2022Peer-reviewedNeuroscience