Yongmin Mason Park

The paper demonstrates that PET/CT imaging with 11C-acetate and 18F-FDG can visualize reactive astrocyte-mediated neuronal hypometabolism in Alzheimer's disease.

The paper identifies ALDH1A1 and SIRT2 as enzymes in the astrocytic putrescine-to-GABA metabolic pathway and suggests they are potential therapeutic targets for Alzheimer's Disease.

This study identifies TMEM43 as a pH-sensing cation channel that modulates gap junction networks in the hippocampus, preventing neuronal hyperexcitability and supporting memory retrieval.

This study shows that astrocytic urea cycle detoxifies Aβ-derived ammonia but impairs memory in Alzheimer's disease, suggesting ODC1 inhibition as a potential therapeutic strategy.